The PSENEN antibody from MyBioSource.com is a Rabbit Polyclonal antibody to PSENEN. This antibody recognizes Human antigen. The PSENEN antibody has been validated for the following applications: Western Blot.
Description
Affinity purified rabbit polyclonal PSENEN antibody
Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase